TY - JOUR
T1 - Early childhood psychosocial family risks and cumulative dopaminergic sensitizing score
T2 - Links to behavior problems in U.S. 9-year-olds
AU - Mullola, Sari
AU - Brooks-Gunn, Jeanne
AU - Elovainio, Marko
AU - Hakulinen, Christian
AU - Schneper, Lisa M.
AU - Notterman, Daniel A.
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - Background: We examined, (a) whether in early childhood exposure to risky family environment in different domains (socioeconomic, mental, parenting practices, health behavior, and child-related risks) and accumulatively across various domains (cumulative risk) is associated with child's problem behavior at age 9, and (b) whether the association is more pronounced in children carrying cumulative dopaminergic sensitizing genotype or living in low-income families. Methods: Participants were 2,860 9-year old children (48% females; 48% Black) and their mothers from the ‘Fragile Families and Child Wellbeing Study’, a probability birth cohort from large U.S. cities. Mothers responded to questions on child's problem behavior (CBCL). Children responded to questions about their vandalism and substance use. Results: Cumulative family risk was associated with higher internalizing and externalizing behavior and higher vandalism and substance use. All domain-specific risk clusters were associated with higher internalizing behavior and, with the exception of child-related risk, with higher externalizing behavior. Mental health risks, risky parenting practices, and risky health behavior were associated with higher vandalism. Risky parenting practices were associated with higher substance use. The associations were robust to adjustment for cumulative dopaminergic sensitizing genotype. No G x E interactions with dopaminergic genotype and family SES were observed. Limitations: Sample size was relatively small for genetic analysis and polygenic risk scores were not available. Conclusions: Exposure to cumulative psychosocial family risks from early childhood is associated with early indicators of problem behavior in adolescence.
AB - Background: We examined, (a) whether in early childhood exposure to risky family environment in different domains (socioeconomic, mental, parenting practices, health behavior, and child-related risks) and accumulatively across various domains (cumulative risk) is associated with child's problem behavior at age 9, and (b) whether the association is more pronounced in children carrying cumulative dopaminergic sensitizing genotype or living in low-income families. Methods: Participants were 2,860 9-year old children (48% females; 48% Black) and their mothers from the ‘Fragile Families and Child Wellbeing Study’, a probability birth cohort from large U.S. cities. Mothers responded to questions on child's problem behavior (CBCL). Children responded to questions about their vandalism and substance use. Results: Cumulative family risk was associated with higher internalizing and externalizing behavior and higher vandalism and substance use. All domain-specific risk clusters were associated with higher internalizing behavior and, with the exception of child-related risk, with higher externalizing behavior. Mental health risks, risky parenting practices, and risky health behavior were associated with higher vandalism. Risky parenting practices were associated with higher substance use. The associations were robust to adjustment for cumulative dopaminergic sensitizing genotype. No G x E interactions with dopaminergic genotype and family SES were observed. Limitations: Sample size was relatively small for genetic analysis and polygenic risk scores were not available. Conclusions: Exposure to cumulative psychosocial family risks from early childhood is associated with early indicators of problem behavior in adolescence.
KW - Antisocial behavior
KW - Cumulative dopaminergic sensitizing score
KW - Cumulative family risk
KW - Domain-specific family risk
KW - Problem behavior
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U2 - 10.1016/j.jad.2020.11.026
DO - 10.1016/j.jad.2020.11.026
M3 - Article
C2 - 33227672
AN - SCOPUS:85096692496
SN - 0165-0327
VL - 280
SP - 432
EP - 441
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -