TY - JOUR
T1 - Dynamics of maternal morphogen gradients in Drosophila
AU - Shvartsman, Stanislav Y.
AU - Coppey, Mathieu
AU - Berezhkovskii, Alexander M.
N1 - Funding Information:
We thank A Boettiger, R De Lotto, O Grimm, G Jimenez, Y Kim, J Lippincott-Schwartz, M Mavrakis, Z Paroush, E Wieschaus, and T Schüpbach for helpful discussions. SYS was supported by the P50 GM071508 and R01GM078079 NIH grants and the NSF CAREER award. AMB was supported by the Intramural Research Program of the NIH, Center for Information Technology.
PY - 2008/8
Y1 - 2008/8
N2 - The first direct studies of morphogen gradients were done in the end of 1980s, in the early Drosophila embryo, which is patterned under the action of four maternally determined morphogens. Since the early studies of maternal morphogens were done with fixed embryos, they were viewed as relatively static signals. Several recent studies analyze dynamics of the anterior, dorsoventral, and terminal patterning signals. The results of these quantitative studies provide critical tests of classical models and reveal new modes of morphogen regulation and readout in one of the most extensively studied patterning systems.
AB - The first direct studies of morphogen gradients were done in the end of 1980s, in the early Drosophila embryo, which is patterned under the action of four maternally determined morphogens. Since the early studies of maternal morphogens were done with fixed embryos, they were viewed as relatively static signals. Several recent studies analyze dynamics of the anterior, dorsoventral, and terminal patterning signals. The results of these quantitative studies provide critical tests of classical models and reveal new modes of morphogen regulation and readout in one of the most extensively studied patterning systems.
UR - http://www.scopus.com/inward/record.url?scp=53549096519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53549096519&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2008.06.002
DO - 10.1016/j.gde.2008.06.002
M3 - Review article
C2 - 18602472
AN - SCOPUS:53549096519
SN - 0959-437X
VL - 18
SP - 342
EP - 347
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 4
ER -