Dynamic switching enables efficient bacterial colonization in flow

Anerudh Kannan, Zhenbin Yang, Minyoung Kevin Kim, Howard A. Stone, Albert Siryaporn

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Bacteria colonize environments that contain networks of moving fluids, including digestive pathways, blood vasculature in animals, and the xylem and phloem networks in plants. In these flow networks, bacteria form distinct biofilm structures that have an important role in pathogenesis. The physical mechanisms that determine the spatial organization of bacteria in flow are not understood. Here, we show that the bacterium P. aeruginosa colonizes flow networks using a cyclical process that consists of surface attachment, upstream movement, detachment, movement with the bulk flow, and surface reattachment. This process, which we have termed dynamic switching, distributes bacterial subpop-ulations upstream and downstream in flow through two phases: movement on surfaces and cellular movement via the bulk. The model equations that describe dynamic switching are identical to those that describe dynamic instability, a process that enables microtubules in eukaryotic cells to search space efficiently to capture chromosomes. Our results show that dynamic switching enables bacteria to explore flow networks efficiently, which maximizes dispersal and colonization and establishes the organizational structure of biofilms. A number of eukaryotic and mammalian cells also exhibit movement in two phases in flow, which suggests that dynamic switching is a modality that enables efficient dispersal for a broad range of cell types.

Original languageEnglish (US)
Pages (from-to)5438-5443
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number21
DOIs
StatePublished - May 22 2018

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • Bacterial dispersal
  • Bacterial mechanics
  • Biofilm organization
  • Colonization dynamics
  • P. aeruginosa

Fingerprint Dive into the research topics of 'Dynamic switching enables efficient bacterial colonization in flow'. Together they form a unique fingerprint.

Cite this