TY - JOUR
T1 - Dynamic Perspectives on the Search for a Universal Influenza Vaccine
AU - Saad-Roy, Chadi M.
AU - McDermott, Adrian B.
AU - Grenfell, Bryan T.
N1 - Funding Information:
This work was funded by the following: Intramural Research Program of the Vaccine Research Center and the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH); the Bill and Melinda Gates Foundation Grant OPP1091919; the RAPIDD program of the Science and Technology Directorate Department of Homeland Security and the Fogarty International Center, NIH; the James S. McDonnell Foundation 21st Century Science Initiative Collaborative Award in Understanding Dynamic and Multi-scale Systems; and the Natural Sciences and Engineering Research Council of Canada through a Postgraduate Scholarship-Doctoral (to C. M. S.-R.)
Publisher Copyright:
© 2019 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
PY - 2019/4/8
Y1 - 2019/4/8
N2 - A universal influenza vaccine (UIV) could considerably alleviate the public health burden of both seasonal and pandemic influenza. Although significant progress has been achieved in clarifying basic immunology and virology relating to UIV, several important questions relating to the dynamics of infection, immunity, and pathogen evolution remain unsolved. In this study, we review these gaps, which span integrative levels, from cellular to global and timescales from molecular events to decades. We argue that they can be best addressed by a tight integration of empirical (laboratory, epidemiological) research and theory and suggest fruitful areas for this synthesis. In particular, quantifying natural and vaccinal limitations on viral transmission are central to this effort.
AB - A universal influenza vaccine (UIV) could considerably alleviate the public health burden of both seasonal and pandemic influenza. Although significant progress has been achieved in clarifying basic immunology and virology relating to UIV, several important questions relating to the dynamics of infection, immunity, and pathogen evolution remain unsolved. In this study, we review these gaps, which span integrative levels, from cellular to global and timescales from molecular events to decades. We argue that they can be best addressed by a tight integration of empirical (laboratory, epidemiological) research and theory and suggest fruitful areas for this synthesis. In particular, quantifying natural and vaccinal limitations on viral transmission are central to this effort.
KW - Influenza vaccination
KW - Shedding-transmission relationship
KW - Viral eco-evolutionary dynamics
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U2 - 10.1093/infdis/jiz044
DO - 10.1093/infdis/jiz044
M3 - Review article
C2 - 30715467
AN - SCOPUS:85064507106
SN - 0022-1899
VL - 219
SP - S46-S56
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -