TY - JOUR
T1 - Dynamic changes in epithelial cell packing during tissue morphogenesis
AU - Lemke, Sandra B.
AU - Nelson, Celeste M.
N1 - Funding Information:
Work from the authors’ group was supported in part by grants from the National Institutes of Health (HL120142, HD079030, CA214292) and a Faculty Scholars Award from the Howard Hughes Medical Institute. S.B.L. was supported in part by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; 459686752 ). The authors thank Payam Farahani for providing the microscopy data used for generating Figure 1 E.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/9/27
Y1 - 2021/9/27
N2 - Cell packing — the spatial arrangement of cells — determines the shapes of organs. Recently, investigations of organ development in a variety of model organisms have uncovered cellular mechanisms that are used by epithelial tissues to change cell packing, and thereby their shapes, to generate functional architectures. Here, we review these cellular mechanisms across a wide variety of developmental processes in vertebrates and invertebrates and identify a set of common motifs in the morphogenesis toolbox that, in combination, appear to allow any change in tissue shape. We focus on tissue elongation, folding and invagination, and branching. We also highlight how these morphogenetic processes are achieved by cell-shape changes, cell rearrangements, and oriented cell division. Finally, we describe approaches that have the potential to engineer three-dimensional tissues for both basic science and translational purposes. This review provides a framework for future analyses of how tissues are shaped by the dynamics of epithelial cell packing.
AB - Cell packing — the spatial arrangement of cells — determines the shapes of organs. Recently, investigations of organ development in a variety of model organisms have uncovered cellular mechanisms that are used by epithelial tissues to change cell packing, and thereby their shapes, to generate functional architectures. Here, we review these cellular mechanisms across a wide variety of developmental processes in vertebrates and invertebrates and identify a set of common motifs in the morphogenesis toolbox that, in combination, appear to allow any change in tissue shape. We focus on tissue elongation, folding and invagination, and branching. We also highlight how these morphogenetic processes are achieved by cell-shape changes, cell rearrangements, and oriented cell division. Finally, we describe approaches that have the potential to engineer three-dimensional tissues for both basic science and translational purposes. This review provides a framework for future analyses of how tissues are shaped by the dynamics of epithelial cell packing.
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U2 - 10.1016/j.cub.2021.07.078
DO - 10.1016/j.cub.2021.07.078
M3 - Review article
C2 - 34582821
AN - SCOPUS:85115755662
SN - 0960-9822
VL - 31
SP - R1098-R1110
JO - Current Biology
JF - Current Biology
IS - 18
ER -