Abstract
RNA modifications are ubiquitous regulators of gene expression processes across biology. Recent studies have begun to decipher the molecular mechanisms underlying the function of diverse RNA modifications and establish links to a variety of human diseases. In this chapter, we provide an overview of the most prevalent modifications found in mRNA, tRNA, and rRNA and highlight their relevance to disease pathogenesis. Further, we aim to illuminate current strategies to target the enzymes responsible for regulating these modifications as an approach to treat disease.
| Original language | English (US) |
|---|---|
| Title of host publication | RNA as a Drug Target |
| Subtitle of host publication | The Next Frontier for Medicinal Chemistry |
| Publisher | Wiley-VCH Verlag |
| Pages | 321-354 |
| Number of pages | 34 |
| ISBN (Electronic) | 9783527840458 |
| ISBN (Print) | 9783527351008 |
| DOIs | |
| State | Published - Jul 5 2024 |
All Science Journal Classification (ASJC) codes
- General Medicine
- General Pharmacology, Toxicology and Pharmaceutics
- General Chemistry
Keywords
- Epitranscriptome
- Inosine
- MRNA
- Non-coding RNA
- Pseudouridine
- RNA modifications
- RNA-modifying enzyme
- RRNA
- TRNA
- mA