Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling

Yan Yan, Natalie Denef, Charm Tang, Trudi Schüpbach

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

In a genetic screen we isolated mutations in CG10260, which encodes a phosphatidylinositol 4-kinase (PI4KIIIalpha), and found that PI4KIIIalpha is required for Hippo signaling in Drosophila ovarian follicle cells. PI4KIIIalpha mutations in the posterior follicle cells lead to oocyte polarization defects similar to those caused by mutations in the Hippo signaling pathway. PI4KIIIalpha mutations also cause misexpression of well-established Hippo signaling targets. The Merlin-Expanded-Kibra complex is required at the apical membrane for Hippo activity. In PI4KIIIalpha mutant follicle cells, Merlin fails to localize to the apical domain. Our analysis of PI4KIIIalpha mutants provides a new link in Hippo signal transduction from the cell membrane to its core kinase cascade.

Original languageEnglish (US)
Pages (from-to)1697-1703
Number of pages7
JournalDevelopment
Volume138
Issue number9
DOIs
StatePublished - May 2011

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Keywords

  • Drosophila
  • Hippo signaling
  • Merlin
  • Oocyte polarity
  • PI4 kinase

Fingerprint Dive into the research topics of 'Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling'. Together they form a unique fingerprint.

  • Cite this