@article{9e9c35853bfa440ba8155396ea84eb22,
title = "Drosophila exocyst components sec5, sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane",
abstract = "The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane. Furthermore, Rab11 and Armadillo interact with the exocyst components Sec15 and Sec10, respectively. Our results support a model whereby the exocyst regulates DE-Cadherin trafficking, from recycling endosomes to sites on the epithelial cell membrane where Armadillo is located.",
author = "Johanna Langevin and Morgan, {Matthew J.} and Carine Ross{\'e} and Victor Racine and Sibarita, {Jean Baptiste} and Sandra Aresta and Mala Murthy and Thomas Schwarz and Jacques Camonis and Yohanns Bella{\"i}che",
note = "Funding Information: Y.B. and J.L. thank F. Schweisguth (Ecole Normale Sup{\'e}rieure, UMR 8544, Paris, France) for support at the beginning of this project. We thank K. Basler, H. Bellen, P. Bryant, H. Oda, R. Cohen, G. Gonzales, D. Ready, J. Sisson, W. Sullivan, A. Wodarz, A. Zahraoui, the Developmental Studies Hybridoma Bank, and the Bloomington Stock Center for strains and antibodies. We thank J. Salamero and V. Fraisier for advice including confocal microscopy. The exocyst two-hybrid screen would not have been possible without the contribution of P. Chavrier (Institut Curie). Y.B. thanks A. Morineau for encouragement and support. We thank N. David, A. Echard, R. Le Borgne, and J. Young for critical reading of the manuscript. This work was supported by grants from the Association pour la Recherche sur le Cancer (ARC 4726 and ARC 7744 to Y.B. and ARC 5440 to J.C.), the F{\'e}d{\'e}ration pour la Recherche M{\'e}dicale, the CNRS, the Curie Institute, grants from the Ministry of Research (ACI program grants), and GenHomme Network Grant (02490-6088) to Hybrigenics and Institut Curie. ",
year = "2005",
month = sep,
doi = "10.1016/j.devcel.2005.07.013",
language = "English (US)",
volume = "9",
pages = "365--376",
journal = "Developmental cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "3",
}