Drosophila exocyst components sec5, sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane

Johanna Langevin, Matthew J. Morgan, Carine Rossé, Victor Racine, Jean Baptiste Sibarita, Sandra Aresta, Mala Murthy, Thomas Schwarz, Jacques Camonis, Yohanns Bellaïche

Research output: Contribution to journalArticle

197 Scopus citations

Abstract

The E-Cadherin-catenin complex plays a critical role in epithelial cell-cell adhesion, polarization, and morphogenesis. Here, we have analyzed the mechanism of Drosophila E-Cadherin (DE-Cad) localization. Loss of function of the Drosophila exocyst components sec5, sec6, and sec15 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane. Furthermore, Rab11 and Armadillo interact with the exocyst components Sec15 and Sec10, respectively. Our results support a model whereby the exocyst regulates DE-Cadherin trafficking, from recycling endosomes to sites on the epithelial cell membrane where Armadillo is located.

Original languageEnglish (US)
Pages (from-to)365-376
Number of pages12
JournalDevelopmental cell
Volume9
Issue number3
DOIs
StatePublished - Sep 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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    Langevin, J., Morgan, M. J., Rossé, C., Racine, V., Sibarita, J. B., Aresta, S., Murthy, M., Schwarz, T., Camonis, J., & Bellaïche, Y. (2005). Drosophila exocyst components sec5, sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane. Developmental cell, 9(3), 365-376. https://doi.org/10.1016/j.devcel.2005.07.013