Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development

Yashi Ahmed, Ali Nouri, Eric Wieschaus

Research output: Contribution to journalReview article

81 Scopus citations

Abstract

Inactivation of the Adenomatous Polyposis Coli (APC) tumor suppressor triggers the development of most colorectal carcinomas. APC is required for targeted degradation of β-catenin, the central transcriptional activator in the Wnt/Wingless (Wg) signal transduction pathway; however, the precise biochemical functions of APC remain uncertain. The two Drosophila homologs of APC (Apc1 and Apc2) appear to have predominantly different tissue distributions, different subcellular localizations and mutually exclusive phenotypes upon inactivation. Unexpectedly, we have found that despite these differences, simultaneous reduction in both Drosophila Apc proteins results in the global nuclear accumulation of β-catenin and the constitutive activation of Wg transduction throughout development. This redundancy extends even to functions previously thought to be specific to the individual Apc homologs. Together, these results reveal that the combined activity of Apc1 and Apc2 allows a tight regulation of transcriptional activation by β-catenin and suggest that APC proteins are required for the regulation of Wnt transduction in all cells.

Original languageEnglish (US)
Pages (from-to)1751-1762
Number of pages12
JournalDevelopment
Volume129
Issue number7
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

Keywords

  • APC
  • Drosophila
  • Transduction
  • Wingless
  • β-catenin

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