Dreams, hallucinations, and psychosis - the serotonin connection

Barry L. Jacobs, Michael E. Trulson

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Dreams, drug-induced hallucinations, and certain aspects of psychosis share common psychic and behavioural properties. Research in our laboratory, and in other laboratories throughout the world, has led us to the conclusion that these phenomenological similarities are based on common neurochemical mechanisms. Based on a multidisciplinary approach employing neurochemical, electrophysiological, neuropharmacological, and behavioural techniques, we have conducted experiments which indicate that decreased serotonergic neurotransmission, possibly coupled with increased dopaminergic function, may be responsible for the manifestation of these common events.

Original languageEnglish (US)
Pages (from-to)276-280
Number of pages5
JournalTrends in Neurosciences
Issue numberC
StatePublished - 1979

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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