Dosage requirements for runt in the segmentation of Drosophila embryos

J. Peter Gergen, Eric Wieschaus

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


The runt gene is required in a Drosophila embryo for normal segmentation. We investigate this requirement by analyzing runt mutations of varying strength and by manipulating wild-type gene dosage. Elimination of runt causes periodic deletions in the segmentation pattern which are spaced at two segment intervals along the antero-posterior axis. The pattern deletions produced by partial loss of function mutations and by halving the normal wild-type gene dosage reveal a gradation in the requirement for runt, with the centers of the affected regions being most sensitive to deletion. Significantly, increased runt+ dosage causes an anti-runt phenotype consisting of periodic pattern deletions that are out of phase with those caused by runt mutations.

Original languageEnglish (US)
Pages (from-to)289-299
Number of pages11
Issue number2
StatePublished - Apr 25 1986

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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