Dorsoventral patterning in Drosophila oogenesis

Trudi Schüpbach; Siegfried Roth

doi:10.1016/0959-437X(94)90064-A

Dorsoventral patterning in Drosophila oogenesis

Trudi Schüpbach, Siegfried Roth

Molecular Biology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Dorsoventral polarity in the egg chamber of Drosophila involves the localization of maternal gurken RNA to the dorsal side of the oocyte. The gurken protein has homology to secreted growth factors and may bind to the torpedo/DER receptor tyrosine kinase present on the adjacent follicle cells. This localized signal from the oocyte to the follicle cells appears to initiate a cascade of events leading to dorsal follicle cell differentiation, and delimiting and orienting the future dorsoventral axis of the embryo.

Original language	English (US)
Pages (from-to)	502-507
Number of pages	6
Journal	Current Opinion in Genetics and Development
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/0959-437X(94)90064-A
State	Published - Aug 1994

All Science Journal Classification (ASJC) codes

Genetics
Developmental Biology

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10.1016/0959-437X(94)90064-A

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title = "Dorsoventral patterning in Drosophila oogenesis",

abstract = "Dorsoventral polarity in the egg chamber of Drosophila involves the localization of maternal gurken RNA to the dorsal side of the oocyte. The gurken protein has homology to secreted growth factors and may bind to the torpedo/DER receptor tyrosine kinase present on the adjacent follicle cells. This localized signal from the oocyte to the follicle cells appears to initiate a cascade of events leading to dorsal follicle cell differentiation, and delimiting and orienting the future dorsoventral axis of the embryo.",

author = "Trudi Sch{\"u}pbach and Siegfried Roth",

note = "Funding Information: We would like to thank Amy Uejsovec, Nancy Hawkins, and Anne Marie Queenan for helpfirl suggestions on the manuscript, and the members of our lab for many stimulating discussions. S IXoth was supported by the Human Frontiers Science Foundation, and the work laboratory is supported by grams from NIH and the Cancer Society.",

year = "1994",

month = aug,

doi = "10.1016/0959-437X(94)90064-A",

language = "English (US)",

volume = "4",

pages = "502--507",

journal = "Current Opinion in Genetics and Development",

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T1 - Dorsoventral patterning in Drosophila oogenesis

AU - Schüpbach, Trudi

AU - Roth, Siegfried

N1 - Funding Information: We would like to thank Amy Uejsovec, Nancy Hawkins, and Anne Marie Queenan for helpfirl suggestions on the manuscript, and the members of our lab for many stimulating discussions. S IXoth was supported by the Human Frontiers Science Foundation, and the work laboratory is supported by grams from NIH and the Cancer Society.

PY - 1994/8

Y1 - 1994/8

N2 - Dorsoventral polarity in the egg chamber of Drosophila involves the localization of maternal gurken RNA to the dorsal side of the oocyte. The gurken protein has homology to secreted growth factors and may bind to the torpedo/DER receptor tyrosine kinase present on the adjacent follicle cells. This localized signal from the oocyte to the follicle cells appears to initiate a cascade of events leading to dorsal follicle cell differentiation, and delimiting and orienting the future dorsoventral axis of the embryo.

AB - Dorsoventral polarity in the egg chamber of Drosophila involves the localization of maternal gurken RNA to the dorsal side of the oocyte. The gurken protein has homology to secreted growth factors and may bind to the torpedo/DER receptor tyrosine kinase present on the adjacent follicle cells. This localized signal from the oocyte to the follicle cells appears to initiate a cascade of events leading to dorsal follicle cell differentiation, and delimiting and orienting the future dorsoventral axis of the embryo.

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Dorsoventral patterning in Drosophila oogenesis

Abstract

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