Dopaminergic modulation of sensory responses of striatal neurons: single unit studies

Elizabeth D. Abercrombie, Barry L. Jacobs

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The extracellular single unit responses of striatal neurons to repetitive stimulation of the sciatic nerve were recorded in the urethane anesthetized rat. Changes in the magnitude of these responses after pharmacological manipulation of dopamine (DA) neurotransmission were evaluated. While the intravenous administration of 0.25 mg/kg i.v. amphetamine (AMPH) had no significant effect on baseline firing rates as compared to saline controls, the magnitudes of excitatory and inhibitory evoked single unit responses were significantly decreased by 68% by AMPH. Further, this reduction in response magnitude produce by AMPH was completely blocked by pretreatment with 0.5 mg/kg i.v. haloperidol or by intrastriatal 6-hydroxydopamine lesions. This indicates that the observed effect is mediated by dopamine located in nerve terminals within the striatum. These results suggest that DA functions to modulate the responsiveness of striatal neurons to afferent signals.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalBrain Research
Volume358
Issue number1-2
DOIs
StatePublished - Dec 9 1985

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • amphetamine
  • dopamine
  • modulation
  • sensory stimulation
  • single unit activity
  • striatum

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