Dopamine transients are sufficient and necessary for acquisition of model-based associations

Melissa J. Sharpe, Chun Yun Chang, Melissa A. Liu, Hannah M. Batchelor, Lauren E. Mueller, Joshua L. Jones, Yael Niv, Geoffrey Schoenbaum

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Associative learning is driven by prediction errors. Dopamine transients correlate with these errors, which current interpretations limit to endowing cues with a scalar quantity reflecting the value of future rewards. We tested whether dopamine might act more broadly to support learning of an associative model of the environment. Using sensory preconditioning, we show that prediction errors underlying stimulus-stimulus learning can be blocked behaviorally and reinstated by optogenetically activating dopamine neurons. We further show that suppressing the firing of these neurons across the transition prevents normal stimulus-stimulus learning. These results establish that the acquisition of model-based information about transitions between nonrewarding events is also driven by prediction errors and that, contrary to existing canon, dopamine transients are both sufficient and necessary to support this type of learning. Our findings open new possibilities for how these biological signals might support associative learning in the mammalian brain in these and other contexts.

Original languageEnglish (US)
Pages (from-to)735-742
Number of pages8
JournalNature neuroscience
Volume20
Issue number5
DOIs
StatePublished - May 1 2017

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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    Sharpe, M. J., Chang, C. Y., Liu, M. A., Batchelor, H. M., Mueller, L. E., Jones, J. L., Niv, Y., & Schoenbaum, G. (2017). Dopamine transients are sufficient and necessary for acquisition of model-based associations. Nature neuroscience, 20(5), 735-742. https://doi.org/10.1038/nn.4538