Dominant negative regulation of the mouse α-fetoprotein gene in adult liver

Jean Vacher, Shirley Marie Tilghman

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

Transcription of the mouse α-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation she of the α-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.

Original languageEnglish (US)
Pages (from-to)1732-1735
Number of pages4
JournalScience
Volume250
Issue number4988
DOIs
StatePublished - Jan 1 1990

All Science Journal Classification (ASJC) codes

  • General

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