Abstract
Transcription of the mouse α-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation site of the α-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1732-1735 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 250 |
| Issue number | 4988 |
| State | Published - Dec 21 1990 |
All Science Journal Classification (ASJC) codes
- General