Domain formation in the plasma membrane: Roles of nonequilibrium lipid transport and membrane proteins

Jun Fan, Maria Sammalkorpi, Mikko Haataja

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Compositional lipid domains ("lipid rafts") in plasma membranes are believed to be important components of many cellular processes. The mechanisms by which cells regulate the sizes and lifetimes of these spatially extended domains are poorly understood at the moment. Here we show that the competition between phase separation in an immiscible lipid system and active cellular lipid transport processes naturally leads to the formation of such domains. Furthermore, we demonstrate that local interactions with immobile membrane proteins can spatially localize the rafts and lead to further clustering.

Original languageEnglish (US)
Article number178102
JournalPhysical review letters
Volume100
Issue number17
DOIs
StatePublished - Apr 28 2008

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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