Dog10K: An international sequencing effort to advance studies of canine domestication, phenotypes and health

Elaine A. Ostrander; Guo Dong Wang; Greger Larson; Bridgett M. Vonholdt; Brian W. Davis; Vidhya Jagannathan; Christophe Hitte; Robert K. Wayne; Ya Ping Zhang; Catherine André; Erik Axelsson; Adam Boyko; Oliver Forman; Laurent Frantz; Elinor Karlsson; Jeffrey Kidd; Tosso Leeb; Kerstin Lindblad-Toh; Hannes Lohi; Kirk E. Lohmueller; Tomas Marques-Bonet; Catherine Mellersh; Peter Savolainen; Robert Schnabel; Ziheng Yang; Weiwei Zhai

doi:10.1093/nsr/nwz049

Dog10K: An international sequencing effort to advance studies of canine domestication, phenotypes and health

Elaine A. Ostrander, Guo Dong Wang, Greger Larson, Bridgett M. Vonholdt, Brian W. Davis, Vidhya Jagannathan, Christophe Hitte, Robert K. Wayne, Ya Ping Zhang, Catherine André, Erik Axelsson, Adam Boyko, Oliver Forman, Laurent Frantz, Elinor Karlsson, Jeffrey Kidd, Tosso Leeb, Kerstin Lindblad-Toh, Hannes Lohi, Kirk E. LohmuellerTomas Marques-Bonet, Catherine Mellersh, Peter Savolainen, Robert Schnabel, Ziheng Yang, Weiwei Zhai

Research output: Contribution to journal › Review article › peer-review

72 Scopus citations

Abstract

Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.

Original language	English (US)
Pages (from-to)	810-824
Number of pages	15
Journal	National Science Review
Volume	6
Issue number	4
DOIs	https://doi.org/10.1093/nsr/nwz049
State	Published - Jul 1 2019

All Science Journal Classification (ASJC) codes

General

Keywords

breed
evolution
genome-wide association studies (GWAS)
genomics
selection
variation

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10.1093/nsr/nwz049

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Ostrander, E. A., Wang, G. D., Larson, G., Vonholdt, B. M., Davis, B. W., Jagannathan, V., Hitte, C., Wayne, R. K., Zhang, Y. P., André, C., Axelsson, E., Boyko, A., Forman, O., Frantz, L., Karlsson, E., Kidd, J., Leeb, T., Lindblad-Toh, K., Lohi, H., ... Zhai, W. (2019). Dog10K: An international sequencing effort to advance studies of canine domestication, phenotypes and health. National Science Review, 6(4), 810-824. https://doi.org/10.1093/nsr/nwz049

@article{26b0286100c04981bdf36bdf083d091a,

title = "Dog10K: An international sequencing effort to advance studies of canine domestication, phenotypes and health",

abstract = "Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.",

keywords = "breed, evolution, genome-wide association studies (GWAS), genomics, selection, variation",

author = "Ostrander, {Elaine A.} and Wang, {Guo Dong} and Greger Larson and Vonholdt, {Bridgett M.} and Davis, {Brian W.} and Vidhya Jagannathan and Christophe Hitte and Wayne, {Robert K.} and Zhang, {Ya Ping} and Catherine Andr{\'e} and Erik Axelsson and Adam Boyko and Oliver Forman and Laurent Frantz and Elinor Karlsson and Jeffrey Kidd and Tosso Leeb and Kerstin Lindblad-Toh and Hannes Lohi and Lohmueller, {Kirk E.} and Tomas Marques-Bonet and Catherine Mellersh and Peter Savolainen and Robert Schnabel and Ziheng Yang and Weiwei Zhai",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.",

year = "2019",

month = jul,

day = "1",

doi = "10.1093/nsr/nwz049",

language = "English (US)",

volume = "6",

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journal = "National Science Review",

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Ostrander, EA, Wang, GD, Larson, G, Vonholdt, BM, Davis, BW, Jagannathan, V, Hitte, C, Wayne, RK, Zhang, YP, André, C, Axelsson, E, Boyko, A, Forman, O, Frantz, L, Karlsson, E, Kidd, J, Leeb, T, Lindblad-Toh, K, Lohi, H, Lohmueller, KE, Marques-Bonet, T, Mellersh, C, Savolainen, P, Schnabel, R, Yang, Z & Zhai, W 2019, 'Dog10K: An international sequencing effort to advance studies of canine domestication, phenotypes and health', National Science Review, vol. 6, no. 4, pp. 810-824. https://doi.org/10.1093/nsr/nwz049

TY - JOUR

T1 - Dog10K

T2 - An international sequencing effort to advance studies of canine domestication, phenotypes and health

AU - Ostrander, Elaine A.

AU - Wang, Guo Dong

AU - Larson, Greger

AU - Vonholdt, Bridgett M.

AU - Davis, Brian W.

AU - Jagannathan, Vidhya

AU - Hitte, Christophe

AU - Wayne, Robert K.

AU - Zhang, Ya Ping

AU - André, Catherine

AU - Axelsson, Erik

AU - Boyko, Adam

AU - Forman, Oliver

AU - Frantz, Laurent

AU - Karlsson, Elinor

AU - Kidd, Jeffrey

AU - Leeb, Tosso

AU - Lindblad-Toh, Kerstin

AU - Lohi, Hannes

AU - Lohmueller, Kirk E.

AU - Marques-Bonet, Tomas

AU - Mellersh, Catherine

AU - Savolainen, Peter

AU - Schnabel, Robert

AU - Yang, Ziheng

AU - Zhai, Weiwei

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.

AB - Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.

KW - breed

KW - evolution

KW - genome-wide association studies (GWAS)

KW - genomics

KW - selection

KW - variation

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U2 - 10.1093/nsr/nwz049

DO - 10.1093/nsr/nwz049

M3 - Review article

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SN - 2095-5138

VL - 6

SP - 810

EP - 824

JO - National Science Review

JF - National Science Review

IS - 4

ER -

Dog10K: An international sequencing effort to advance studies of canine domestication, phenotypes and health

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