Do G protein subunits associate via a three-stranded coiled coil?

Andrei N. Lupas, Janice M. Lupas, Jeffry B. Stock

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


We used a computer-based prediction algorithm to identify probable coiled-coil segments at the N-termini of G protein α, β and γ subunits. This result indicates that G protein trimers may form via a three-stranded coiled coil. Previous biochemical results had shown that the N-termini of α and β are involved in subunit interactions. Here we present a structural model for the N-terminal domain of βγ and a hypothesis for the reversible association of α to βγ.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalFEBS Letters
Issue number2
StatePublished - Dec 14 1992

All Science Journal Classification (ASJC) codes

  • Genetics
  • Molecular Biology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Cell Biology


  • Coiled coil
  • G protein structure, Transducin βγ dimer
  • G protein trimerization


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