TY - JOUR
T1 - DNA repair at telomeres
T2 - Keeping the ends intact
AU - Webb, Christopher J.
AU - Wu, Yun
AU - Zakian, Virginia A.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/6
Y1 - 2013/6
N2 - Themoleculareraoftelomere biology began withthe discovery that telomeres usually consist of G-rich simple repeats and end with 30 single-stranded tails. Enormous progress has been made in identifying the mechanisms that maintain and replenish telomeric DNA and the proteins that protect them from degradation, fusions, and checkpoint activation. Although telomeresindifferent organisms (oreveninthe same organismunder different conditions) are maintained by different mechanisms, the disparate processes have the common goals of repairing defects caused by semiconservative replication through G-rich DNA, countering the shortening caused by incomplete replication, and postreplication regeneration of G tails. In addition,standardDNA repair mechanismsmustbesuppressedormodifiedattelomeresto preventtheirbeingrecognizedandprocessedasDNA double-strandbreaks.Here,wediscuss the players and processes that maintain and regenerate telomere structure.
AB - Themoleculareraoftelomere biology began withthe discovery that telomeres usually consist of G-rich simple repeats and end with 30 single-stranded tails. Enormous progress has been made in identifying the mechanisms that maintain and replenish telomeric DNA and the proteins that protect them from degradation, fusions, and checkpoint activation. Although telomeresindifferent organisms (oreveninthe same organismunder different conditions) are maintained by different mechanisms, the disparate processes have the common goals of repairing defects caused by semiconservative replication through G-rich DNA, countering the shortening caused by incomplete replication, and postreplication regeneration of G tails. In addition,standardDNA repair mechanismsmustbesuppressedormodifiedattelomeresto preventtheirbeingrecognizedandprocessedasDNA double-strandbreaks.Here,wediscuss the players and processes that maintain and regenerate telomere structure.
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U2 - 10.1101/cshperspect.a012666
DO - 10.1101/cshperspect.a012666
M3 - Article
C2 - 23732473
AN - SCOPUS:84878934258
SN - 1943-0264
VL - 5
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
IS - 6
ER -