Diversity of gene expression in adenocarcinoma of the lung

Mitchell E. Garber, Olga G. Troyanskaya, Karsten Schluens, Simone Petersen, Zsuzsanna Thaesler, Manuela Pacyna-Gengelbach, Matt Van De Rijn, Glenn D. Rosen, Charles M. Perou, Richard I. Whyte, Russ B. Altman, Patrick O. Brown, David Botstein, Iver Petersen

Research output: Contribution to journalArticlepeer-review

1127 Scopus citations


The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.

Original languageEnglish (US)
Pages (from-to)13784-13789
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number24
StatePublished - Nov 20 2001

All Science Journal Classification (ASJC) codes

  • General


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