Diversity of gene expression in adenocarcinoma of the lung

Mitchell E. Garber; Olga G. Troyanskaya; Karsten Schluens; Simone Petersen; Zsuzsanna Thaesler; Manuela Pacyna-Gengelbach; Matt Van De Rijn; Glenn D. Rosen; Charles M. Perou; Richard I. Whyte; Russ B. Altman; Patrick O. Brown; David Botstein; Iver Petersen

doi:10.1073/pnas.241500798

Diversity of gene expression in adenocarcinoma of the lung

Mitchell E. Garber, Olga G. Troyanskaya, Karsten Schluens, Simone Petersen, Zsuzsanna Thaesler, Manuela Pacyna-Gengelbach, Matt Van De Rijn, Glenn D. Rosen, Charles M. Perou, Richard I. Whyte, Russ B. Altman, Patrick O. Brown, David Botstein, Iver Petersen

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1130 Scopus citations

Abstract

The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.

Original language	English (US)
Pages (from-to)	13784-13789
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	98
Issue number	24
DOIs	https://doi.org/10.1073/pnas.241500798
State	Published - Nov 20 2001

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Garber, M. E., Troyanskaya, O. G., Schluens, K., Petersen, S., Thaesler, Z., Pacyna-Gengelbach, M., Van De Rijn, M., Rosen, G. D., Perou, C. M., Whyte, R. I., Altman, R. B., Brown, P. O., Botstein, D., & Petersen, I. (2001). Diversity of gene expression in adenocarcinoma of the lung. Proceedings of the National Academy of Sciences of the United States of America, 98(24), 13784-13789. https://doi.org/10.1073/pnas.241500798

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title = "Diversity of gene expression in adenocarcinoma of the lung",

abstract = "The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.",

author = "Garber, {Mitchell E.} and Troyanskaya, {Olga G.} and Karsten Schluens and Simone Petersen and Zsuzsanna Thaesler and Manuela Pacyna-Gengelbach and {Van De Rijn}, Matt and Rosen, {Glenn D.} and Perou, {Charles M.} and Whyte, {Richard I.} and Altman, {Russ B.} and Brown, {Patrick O.} and David Botstein and Iver Petersen",

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Garber, ME, Troyanskaya, OG, Schluens, K, Petersen, S, Thaesler, Z, Pacyna-Gengelbach, M, Van De Rijn, M, Rosen, GD, Perou, CM, Whyte, RI, Altman, RB, Brown, PO, Botstein, D & Petersen, I 2001, 'Diversity of gene expression in adenocarcinoma of the lung', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 24, pp. 13784-13789. https://doi.org/10.1073/pnas.241500798

TY - JOUR

T1 - Diversity of gene expression in adenocarcinoma of the lung

AU - Garber, Mitchell E.

AU - Troyanskaya, Olga G.

AU - Schluens, Karsten

AU - Petersen, Simone

AU - Thaesler, Zsuzsanna

AU - Pacyna-Gengelbach, Manuela

AU - Van De Rijn, Matt

AU - Rosen, Glenn D.

AU - Perou, Charles M.

AU - Whyte, Richard I.

AU - Altman, Russ B.

AU - Brown, Patrick O.

AU - Botstein, David

AU - Petersen, Iver

PY - 2001/11/20

Y1 - 2001/11/20

N2 - The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.

AB - The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 24

ER -

Diversity of gene expression in adenocarcinoma of the lung

Abstract

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