Diverse effects of obesity on antitumor immunity and immunotherapy

Lydia Dyck, Lydia Lynch

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Currently, obesity is one of the biggest health burdens facing society because it causes several comorbidities, such as type 2 diabetes, atherosclerosis, and heart disease. Obesity is also linked to multiple types of cancer. Obesity is the second most common preventable cause of cancer after smoking; the rates of obesity are increasing worldwide, as are the rates of obesity-associated cancer. Multiple factors link obesity to cancer, such as increased levels of growth hormones and adipokines, gut dysbiosis, altered tumor metabolism, and chronic low-grade inflammation. More recently, obesity has been shown to also affect the immune response against cancer. In this review we discuss the interplay between obesity, the immune system, and cancer.

Original languageEnglish (US)
Pages (from-to)112-123
Number of pages12
JournalTrends in Molecular Medicine
Volume29
Issue number2
DOIs
StatePublished - Feb 2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

Keywords

  • antitumor immunity
  • cancer
  • immunometabolism
  • immunotherapy
  • obesity

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