Distinctions between the two state and sequential models for cooperative ligand binding

R. E. Gibson; Simon Asher Levin

doi:10.1073/pnas.74.1.139

Distinctions between the two state and sequential models for cooperative ligand binding

R. E. Gibson, Simon Asher Levin

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Abstract

The two state and sequential models for positive cooperativity in ligand binding can produce significantly different theoretical binding curves when presented in a Scatchard plot. The conditions that produce the greatest differences have been examined. The theoretical differences have been used to select the two state model as the best model for describing the binding of acetylcholine to acetylcholine receptors that have been solubilized by Triton X 100 and sodium cholate.

Original language	English (US)
Pages (from-to)	139-143
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	74
Issue number	1
DOIs	https://doi.org/10.1073/pnas.74.1.139
State	Published - 1977

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10.1073/pnas.74.1.139

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abstract = "The two state and sequential models for positive cooperativity in ligand binding can produce significantly different theoretical binding curves when presented in a Scatchard plot. The conditions that produce the greatest differences have been examined. The theoretical differences have been used to select the two state model as the best model for describing the binding of acetylcholine to acetylcholine receptors that have been solubilized by Triton X 100 and sodium cholate.",

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Distinctions between the two state and sequential models for cooperative ligand binding

Abstract

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