Abstract
Objective. To determine whether disease predicts weight loss in population-based studies, as this may confound the relationship between weight and mortality. Materials and methods. We used longitudinal data from the Costa Rican Longevity and Healthy Aging Study (CRELES) and the English Longitudinal Study of Ageing (ELSA). We defined two overlapping outcomes of measured weight loss between waves: >1.0 point of body mass index (BMI) and >2.0 BMI points. Logistic regression models estimated the associations with disease, adjusting for age (range 52-79), sex, smoking, and initial BMI. Results. In ELSA, onset of diabetes, cancer, or lung disease is associated with loss >2.0 points (respectively, OR=2.25 [95%CI: 1.34-3.80]; OR=2.70 [95%CI: 1.49-4.89]; OR=1.82 [95%CI: 1.02-3.26]). In CRELES, disease-onset reports are not associated with weight loss at 5% significance, but statistical power to detect associations is poor. Conclusion. Although it is known that some diseases cause weight loss, at the population level these associations vary considerably across samples.
Original language | English (US) |
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Pages (from-to) | 312-319 |
Number of pages | 8 |
Journal | Salud Publica de Mexico |
Volume | 57 |
Issue number | 4 |
DOIs | |
State | Published - 2015 |
All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
Keywords
- Body mass index
- Body weight changes
- Costa Rica
- Diabetes mellitus
- England
- Weight loss