Discovery of quorum quenchers targeting the membrane-embedded sensor domain of theStaphylococcus aureusreceptor histidine kinase, AgrC

Qian Xie, Mareike M. Wiedmann, Aishan Zhao, Ivelisse R. Pagan, Richard P. Novick, Hiroaki Suga, Tom W. Muir

Research output: Contribution to journalArticle

Abstract

We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors ofStaphylococcus aureusquorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.

Original languageEnglish (US)
Pages (from-to)11223-11226
Number of pages4
JournalChemical Communications
Volume56
Issue number76
DOIs
StatePublished - Sep 28 2020

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Discovery of quorum quenchers targeting the membrane-embedded sensor domain of theStaphylococcus aureusreceptor histidine kinase, AgrC'. Together they form a unique fingerprint.

Cite this