Discovery of quorum quenchers targeting the membrane-embedded sensor domain of theStaphylococcus aureusreceptor histidine kinase, AgrC

Qian Xie; Mareike M. Wiedmann; Aishan Zhao; Ivelisse R. Pagan; Richard P. Novick; Hiroaki Suga; Tom W. Muir

doi:10.1039/d0cc04873a

Discovery of quorum quenchers targeting the membrane-embedded sensor domain of theStaphylococcus aureusreceptor histidine kinase, AgrC

Qian Xie, Mareike M. Wiedmann, Aishan Zhao, Ivelisse R. Pagan, Richard P. Novick, Hiroaki Suga, Tom W. Muir

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors ofStaphylococcus aureusquorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.

Original language	English (US)
Pages (from-to)	11223-11226
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	76
DOIs	https://doi.org/10.1039/d0cc04873a
State	Published - Sep 28 2020

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/d0cc04873a

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abstract = "We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors ofStaphylococcus aureusquorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.",

author = "Qian Xie and Wiedmann, {Mareike M.} and Aishan Zhao and Pagan, {Ivelisse R.} and Novick, {Richard P.} and Hiroaki Suga and Muir, {Tom W.}",

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AU - Xie, Qian

AU - Wiedmann, Mareike M.

AU - Zhao, Aishan

AU - Pagan, Ivelisse R.

AU - Novick, Richard P.

AU - Suga, Hiroaki

AU - Muir, Tom W.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2020.

PY - 2020/9/28

Y1 - 2020/9/28

N2 - We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors ofStaphylococcus aureusquorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.

AB - We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors ofStaphylococcus aureusquorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.

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JF - Chemical Communications

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ER -

Discovery of quorum quenchers targeting the membrane-embedded sensor domain of theStaphylococcus aureusreceptor histidine kinase, AgrC

Abstract

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