Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Brianna B. Williams, Andrew H. Van Benschoten, Peter Cimermancic, Mohamed S. Abou Donia, Michael Zimmermann, Mao Taketani, Atsushi Ishihara, Purna C. Kashyap, James S. Fraser, Michael A. Fischbach

Research output: Contribution to journalArticle

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Abstract

Gut microbiota produce tryptamine via tryptophan (Trp) decarboxylationTwo bacterial Trp decarboxylases from gut Firmicutes were identified and characterizedStructure of one of the tryptophan decarboxylase suggests catalytic mechanism>10% of healthy humans harbor a Trp decarboxylase in their gut microbiome

Original languageEnglish (US)
Pages (from-to)495-503
Number of pages9
JournalCell Host and Microbe
Volume16
Issue number4
DOIs
StatePublished - Oct 8 2014

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Virology

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    Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Abou Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S., & Fischbach, M. A. (2014). Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host and Microbe, 16(4), 495-503. https://doi.org/10.1016/j.chom.2014.09.001