Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Brianna B. Williams; Andrew H. Van Benschoten; Peter Cimermancic; Mohamed S. Abou Donia; Michael Zimmermann; Mao Taketani; Atsushi Ishihara; Purna C. Kashyap; James S. Fraser; Michael A. Fischbach

doi:10.1016/j.chom.2014.09.001

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Brianna B. Williams, Andrew H. Van Benschoten, Peter Cimermancic, Mohamed S. Abou Donia, Michael Zimmermann, Mao Taketani, Atsushi Ishihara, Purna C. Kashyap, James S. Fraser, Michael A. Fischbach

Research output: Contribution to journal › Article › peer-review

223 Scopus citations

Abstract

Gut microbiota produce tryptamine via tryptophan (Trp) decarboxylationTwo bacterial Trp decarboxylases from gut Firmicutes were identified and characterizedStructure of one of the tryptophan decarboxylase suggests catalytic mechanism>10% of healthy humans harbor a Trp decarboxylase in their gut microbiome

Original language	English (US)
Pages (from-to)	495-503
Number of pages	9
Journal	Cell Host and Microbe
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2014.09.001
State	Published - Oct 8 2014

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Virology

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10.1016/j.chom.2014.09.001

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Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Abou Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S., & Fischbach, M. A. (2014). Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host and Microbe, 16(4), 495-503. https://doi.org/10.1016/j.chom.2014.09.001

Williams, Brianna B. ; Van Benschoten, Andrew H. ; Cimermancic, Peter ; Abou Donia, Mohamed S. ; Zimmermann, Michael ; Taketani, Mao ; Ishihara, Atsushi ; Kashyap, Purna C. ; Fraser, James S. ; Fischbach, Michael A. / Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. In: Cell Host and Microbe. 2014 ; Vol. 16, No. 4. pp. 495-503.

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author = "Williams, {Brianna B.} and {Van Benschoten}, {Andrew H.} and Peter Cimermancic and {Abou Donia}, {Mohamed S.} and Michael Zimmermann and Mao Taketani and Atsushi Ishihara and Kashyap, {Purna C.} and Fraser, {James S.} and Fischbach, {Michael A.}",

note = "Funding Information: We are indebted to Justin Rettenmaier for an early computational analysis of candidate decarboxylases from Clostridium sporogenes and to members of the Fischbach group for ideas and helpful discussions. This work was supported by a Fellowship for Science and Engineering from the David and Lucile Packard Foundation (M.A.F.), Medical Research Program Grant from the W.M. Keck Foundation (M.A.F.), DARPA award HR0011-12-C-0067 (M.A.F.), QB3 (J.S.F.), and NIH grants OD007290 and GM081879 (M.A.F.) and OD009180 (J.S.F.), as well as an HHMI Predoctoral Fellowship (P.C.) and NIH K08DK100638 (P.C.K.). Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

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Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. / Williams, Brianna B.; Van Benschoten, Andrew H.; Cimermancic, Peter; Abou Donia, Mohamed S.; Zimmermann, Michael; Taketani, Mao; Ishihara, Atsushi; Kashyap, Purna C.; Fraser, James S.; Fischbach, Michael A.

In: Cell Host and Microbe, Vol. 16, No. 4, 08.10.2014, p. 495-503.

Research output: Contribution to journal › Article › peer-review

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Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

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