Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Brianna B. Williams; Andrew H. Van Benschoten; Peter Cimermancic; Mohamed S. Abou Donia; Michael Zimmermann; Mao Taketani; Atsushi Ishihara; Purna C. Kashyap; James S. Fraser; Michael A. Fischbach

doi:10.1016/j.chom.2014.09.001

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Brianna B. Williams, Andrew H. Van Benschoten, Peter Cimermancic, Mohamed S. Abou Donia, Michael Zimmermann, Mao Taketani, Atsushi Ishihara, Purna C. Kashyap, James S. Fraser, Michael A. Fischbach

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

Gut microbiota produce tryptamine via tryptophan (Trp) decarboxylationTwo bacterial Trp decarboxylases from gut Firmicutes were identified and characterizedStructure of one of the tryptophan decarboxylase suggests catalytic mechanism>10% of healthy humans harbor a Trp decarboxylase in their gut microbiome

Original language	English (US)
Pages (from-to)	495-503
Number of pages	9
Journal	Cell Host and Microbe
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2014.09.001
State	Published - Oct 8 2014

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Virology

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Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Abou Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S., & Fischbach, M. A. (2014). Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host and Microbe, 16(4), 495-503. https://doi.org/10.1016/j.chom.2014.09.001

Williams, Brianna B. ; Van Benschoten, Andrew H. ; Cimermancic, Peter ; Abou Donia, Mohamed S. ; Zimmermann, Michael ; Taketani, Mao ; Ishihara, Atsushi ; Kashyap, Purna C. ; Fraser, James S. ; Fischbach, Michael A. / Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. In: Cell Host and Microbe. 2014 ; Vol. 16, No. 4. pp. 495-503.

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Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. / Williams, Brianna B.; Van Benschoten, Andrew H.; Cimermancic, Peter; Abou Donia, Mohamed S.; Zimmermann, Michael; Taketani, Mao; Ishihara, Atsushi; Kashyap, Purna C.; Fraser, James S.; Fischbach, Michael A.

In: Cell Host and Microbe, Vol. 16, No. 4, 08.10.2014, p. 495-503.

Research output: Contribution to journal › Article › peer-review

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