TY - JOUR
T1 - Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine
AU - Williams, Brianna B.
AU - Van Benschoten, Andrew H.
AU - Cimermancic, Peter
AU - Abou Donia, Mohamed S.
AU - Zimmermann, Michael
AU - Taketani, Mao
AU - Ishihara, Atsushi
AU - Kashyap, Purna C.
AU - Fraser, James S.
AU - Fischbach, Michael A.
N1 - Funding Information:
We are indebted to Justin Rettenmaier for an early computational analysis of candidate decarboxylases from Clostridium sporogenes and to members of the Fischbach group for ideas and helpful discussions. This work was supported by a Fellowship for Science and Engineering from the David and Lucile Packard Foundation (M.A.F.), Medical Research Program Grant from the W.M. Keck Foundation (M.A.F.), DARPA award HR0011-12-C-0067 (M.A.F.), QB3 (J.S.F.), and NIH grants OD007290 and GM081879 (M.A.F.) and OD009180 (J.S.F.), as well as an HHMI Predoctoral Fellowship (P.C.) and NIH K08DK100638 (P.C.K.).
Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/10/8
Y1 - 2014/10/8
N2 - Gut microbiota produce tryptamine via tryptophan (Trp) decarboxylationTwo bacterial Trp decarboxylases from gut Firmicutes were identified and characterizedStructure of one of the tryptophan decarboxylase suggests catalytic mechanism>10% of healthy humans harbor a Trp decarboxylase in their gut microbiome
AB - Gut microbiota produce tryptamine via tryptophan (Trp) decarboxylationTwo bacterial Trp decarboxylases from gut Firmicutes were identified and characterizedStructure of one of the tryptophan decarboxylase suggests catalytic mechanism>10% of healthy humans harbor a Trp decarboxylase in their gut microbiome
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U2 - 10.1016/j.chom.2014.09.001
DO - 10.1016/j.chom.2014.09.001
M3 - Article
C2 - 25263219
AN - SCOPUS:84908072394
VL - 16
SP - 495
EP - 503
JO - Cell Host and Microbe
JF - Cell Host and Microbe
SN - 1931-3128
IS - 4
ER -