Directional transneuronal spread of α-herpesvirus infection

D. Curanovic, L. W. Enquist

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Most α-herpesviruses are pantropic, neuroinvasive pathogens that establish a reactivateable, latent infection in the PNS of their natural hosts. Various manifestations of herpes disease rely on extent and direction of the spread of infection between the surface epithelia and the nervous system components that innervate that surface. One aspect of such controlled spread of infection is the capacity for synaptically defined, transneuronal spread, a property that makes α-herpesviruses useful tools for determining the connectivity of neural circuits. The current understanding of intra-axonal transport and transneuronal spread of α-herpesviruses is reviewed, focusing on work with herpes simplex virus and pseudorabies virus, the available in vitro technology used to study viral transport and spread is evaluated and how certain viral mutants can be used to examine neural circuit architecture is described in this article.

Original languageEnglish (US)
Pages (from-to)591-603
Number of pages13
JournalFuture Virology
Issue number6
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • Virology


  • Axonal
  • Circuit tracing
  • Herpes
  • Pseudorabies virus
  • Simplex virus
  • Sorting axonal transport
  • α-herpesvirus


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