Directed evolution of non-heme iron enzymes to access a non-natural radical-relay C(sp3)−H azidation

Mark R. Petchey; Todd Hyster

doi:10.1016/j.checat.2022.09.040

Directed evolution of non-heme iron enzymes to access a non-natural radical-relay C(sp³)−H azidation

Mark R. Petchey
, Todd Hyster

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Recently in Science, Huang and co-workers applied directed evolution for the improvement of a non-heme iron oxidase to catalyze the enantioselective radical-relay azidation of N-fluoroamide substrates. They demonstrated the synthetic applicability by using the improved variant in a one-pot, two-step chemoenzymatic synthesis of a highly functionalized triazole product.

Original language	English (US)
Pages (from-to)	2449-2451
Number of pages	3
Journal	Chem Catalysis
Volume	2
Issue number	10
DOIs	https://doi.org/10.1016/j.checat.2022.09.040
State	Published - Oct 20 2022
Externally published	Yes

All Science Journal Classification (ASJC) codes

Chemistry (miscellaneous)
Physical and Theoretical Chemistry
Organic Chemistry

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10.1016/j.checat.2022.09.040

Cite this

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title = "Directed evolution of non-heme iron enzymes to access a non-natural radical-relay C(sp3)−H azidation",

abstract = "Recently in Science, Huang and co-workers applied directed evolution for the improvement of a non-heme iron oxidase to catalyze the enantioselective radical-relay azidation of N-fluoroamide substrates. They demonstrated the synthetic applicability by using the improved variant in a one-pot, two-step chemoenzymatic synthesis of a highly functionalized triazole product.",

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AU - Petchey, Mark R.

AU - Hyster, Todd

PY - 2022/10/20

Y1 - 2022/10/20

N2 - Recently in Science, Huang and co-workers applied directed evolution for the improvement of a non-heme iron oxidase to catalyze the enantioselective radical-relay azidation of N-fluoroamide substrates. They demonstrated the synthetic applicability by using the improved variant in a one-pot, two-step chemoenzymatic synthesis of a highly functionalized triazole product.

AB - Recently in Science, Huang and co-workers applied directed evolution for the improvement of a non-heme iron oxidase to catalyze the enantioselective radical-relay azidation of N-fluoroamide substrates. They demonstrated the synthetic applicability by using the improved variant in a one-pot, two-step chemoenzymatic synthesis of a highly functionalized triazole product.

UR - https://www.scopus.com/pages/publications/85140088793

UR - https://www.scopus.com/pages/publications/85140088793#tab=citedBy

U2 - 10.1016/j.checat.2022.09.040

DO - 10.1016/j.checat.2022.09.040

M3 - Comment/debate

AN - SCOPUS:85140088793

SN - 2667-1107

VL - 2

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JO - Chem Catalysis

JF - Chem Catalysis

IS - 10

ER -

Directed evolution of non-heme iron enzymes to access a non-natural radical-relay C(sp³)−H azidation

Abstract

All Science Journal Classification (ASJC) codes

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