Directed evolution of non-heme iron enzymes to access a non-natural radical-relay C(sp3)−H azidation

Mark R. Petchey, Todd Hyster

Research output: Contribution to journalComment/debatepeer-review

Abstract

Recently in Science, Huang and co-workers applied directed evolution for the improvement of a non-heme iron oxidase to catalyze the enantioselective radical-relay azidation of N-fluoroamide substrates. They demonstrated the synthetic applicability by using the improved variant in a one-pot, two-step chemoenzymatic synthesis of a highly functionalized triazole product.

Original languageEnglish (US)
Pages (from-to)2449-2451
Number of pages3
JournalChem Catalysis
Volume2
Issue number10
DOIs
StatePublished - Oct 20 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry (miscellaneous)
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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