Directed assembly of soft colloids through rapid solvent exchange

Arash Nikoubashman, Victoria E. Lee, Chris Sosa, Robert K. Prud'homme, Rodney D. Priestley, Athanassios Z. Panagiotopoulos

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


We studied the directed assembly of soft nanoparticles through rapid micromixing of polymers in solution with a nonsolvent. Both experiments and computer simulations were performed to elucidate the underlying physics and to investigate the role of various process parameters. In particular, we discovered that no external stabilizing agents or charged end groups are required to keep the colloids separated from each other when water is used as the nonsolvent. Furthermore, the size of the nanoparticles can be reliably tuned through the mixing rate and the ratio between polymer solution and nonsolvent. Our results demonstrate that this mechanism is highly promising for the mass fabrication of uniformly sized colloidal particles, using a wide variety of polymeric feed materials.

Original languageEnglish (US)
Pages (from-to)1425-1433
Number of pages9
JournalACS Nano
Issue number1
StatePublished - Jan 26 2016

All Science Journal Classification (ASJC) codes

  • General Engineering
  • General Materials Science
  • General Physics and Astronomy


  • Colloids
  • Experiments
  • Flash nanoprecipitation
  • Self-Assembly
  • Simulation


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