Direct synthesis of pyran-lactones related to naphthoquinoneantibiotics

M. F. Semmelhack, Christina Bodurow, Mary Baum

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Simple benzopyrans with a fused γ-lactone unit are prepared from an o-disubstituted arene by direct intramolecular alkoxycarbonylation/lactonization promoted by palladium diacetate; the process gives high yields and moderate stereoselectivity, favoring the cis lactone over trans by a factor of 5:1.

Original languageEnglish (US)
Pages (from-to)3171-3174
Number of pages4
JournalTetrahedron Letters
Issue number30
StatePublished - 1984

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'Direct synthesis of pyran-lactones related to naphthoquinoneantibiotics'. Together they form a unique fingerprint.

Cite this