Direct C-C Bond Formation from Alkanes Using Ni-Photoredox Catalysis

Laura K.G. Ackerman, Jesus I. Martinez Alvarado, Abigail G. Doyle

Research output: Contribution to journalArticlepeer-review

180 Scopus citations


A method for direct cross coupling between unactivated C(sp3)-H bonds and chloroformates has been accomplished via nickel and photoredox catalysis. A diverse range of feedstock chemicals, such as (a)cyclic alkanes and toluenes, along with late-stage intermediates, undergo intermolecular C-C bond formation to afford esters under mild conditions using only 3 equiv of the C-H partner. Site selectivity is predictable according to bond strength and polarity trends that are consistent with the intermediacy of a chlorine radical as the hydrogen atom-abstracting species.

Original languageEnglish (US)
Pages (from-to)14059-14063
Number of pages5
JournalJournal of the American Chemical Society
Issue number43
StatePublished - Oct 31 2018

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


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