Direct Aldehyde C-H Arylation and Alkylation via the Combination of Nickel, Hydrogen Atom Transfer, and Photoredox Catalysis

Xiaheng Zhang, David W.C. MacMillan

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

A mechanism that enables direct aldehyde C-H functionalization has been achieved via the synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis. This mild, operationally simple protocol transforms a wide variety of commercially available aldehydes, along with aryl or alkyl bromides, into the corresponding ketones in excellent yield. This C-H abstraction coupling technology has been successfully applied to the expedient synthesis of the medicinal agent haloperidol.

Original languageEnglish (US)
Pages (from-to)11353-11356
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number33
DOIs
StatePublished - Aug 23 2017

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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