Abstract
The direct α-arylation of cyclic and acyclic ethers with heteroarenes has been accomplished through the design of a photoredox-mediated C - H functionalization pathway. Transiently generated α-oxyalkyl radicals, produced from a variety of widely available ethers through hydrogen atom transfer (HAT), were coupled with a range of electron-deficient heteroarenes in a Minisci-type mechanism. This mild, visible-light-driven protocol allows direct access to medicinal pharmacophores of broad utility using feedstock substrates and a commercial photocatalyst.
Original language | English (US) |
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Pages (from-to) | 1565-1569 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 54 |
Issue number | 5 |
DOIs | |
State | Published - Jan 26 2015 |
All Science Journal Classification (ASJC) codes
- General Chemistry
- Catalysis
Keywords
- Alkylation
- C-H functionalization
- Ethers
- Heterocycles
- Photoredox catalysis