Diminished adult neurogenesis in the marmoset brain precedes old age

Benedetta Leuner, Yevgenia Kozorovitskiy, Charles G. Gross, Elizabeth Gould

Research output: Contribution to journalArticle

167 Scopus citations

Abstract

With aging there is a decline in the number of newly generated neurons in the dentate gyrus of the hippocampus. In rodents and tree shrews, this age-related decrease in neurogenesis is evident long before the animals become aged. No previous studies have investigated whether primates exhibit a similar decline in hippocampal neurogenesis with aging. To investigate this possibility, young to middle aged adult common marmosets (Callithrix jacchus) were injected with BrdU and perfused 3 weeks later. The number of newly generated cells in the subgranular zone/granule cell layer of the dentate gyrus was significantly lower in older animals and decreased linearly with age. A similar age-related decline in new cells was observed in the subventricular zone but not in the hilar region of the dentate gyrus. These data demonstrate that a substantial decrease in neurogenesis occurs before the onset of old age in the adult marmoset brain, suggesting the possibility that similar alterations occur in the human brain.

Original languageEnglish (US)
Pages (from-to)17169-17173
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number43
DOIs
StatePublished - Oct 23 2007

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • Aging
  • BrdU
  • Dentate gyrus
  • Hippocampus
  • Subventricular zone

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