The direct dimethyl ether(DME) synthesis from syngas containing N 2 was investigated in a fixed-bed reactor over afunctional catalysts in the range of temperature 220-260°C, pressure 3-7MPa and space velocity 500-2000mL·g-1·h-1 At 240°C, 7 MPa and 1000 mL·g-1·h-1, CO conversion was 92.4% and DME selectivity was 86.7% over hybrid catalyst. The results showed that CO conversion increased with the increasing reaction temperature and reaction pressure; the selectivity of DME was insensitive to temperature. The intrinsic kinetics of dimethyl ether synthesis from syngas over the hybrid afunctional catalyst was also studied. The three reactions including methanol synthesis from CO and H2, methanol synthesis from CO2 and H2, and methanol dehydration were chosen as the independent reactions. The data were fit to Langmuir Hinshelwood kinetics; kinetic parameters were obtained by using simplex method combined with genetic algorithm. CO conversion over hybrid bifunctional catalyst showed improved fields compared to sequential reactors with methanol synthesis and methanol dehydration catalysts.