Digital selection and analogue amplification coexist in a cortex- inspired silicon circuit

Richard H.R. Hahnioser, Rahul Sarpeshkar, Misha A. Mahowald, Rodney J. Douglas, Hyunjune Sebastian Seung

Research output: Contribution to journalArticle

475 Scopus citations

Abstract

Digital circuits such as the flip-flop use feedback to achive multistability and nonlinearity to restore signals to logical levels, for example 0 and 1. Analogue feedback circuits are generally designed to operate linearly, so that signals are over a range, and the response is unique. By contrast, the response of cortical circuits to sensory stimulation can be both mustistable and graded. We propose that the neocortex combines digital selection of an active set of neurons with analogue response by dynamically varying the positive feedback inherent in its recurrent connections. Strong positive feedback causes differential instabilities that drive the selection of a set of active neurons under the constraints embedded in the synaptic weights. Once selected, the active neurons generate weaker, stable feedback that provides analogue amplification of the input. Here we present our model of cortical processing as an electronic circuit that emulates this hybrid operation, and so is able to perform computations that are similar to stimulus selection, gain modulation and spatio-temporal pattern generation in the neocortex.

Original languageEnglish (US)
Pages (from-to)947-951
Number of pages5
JournalNature
Volume405
Issue number6789
DOIs
StatePublished - Jun 22 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • General

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    Hahnioser, R. H. R., Sarpeshkar, R., Mahowald, M. A., Douglas, R. J., & Seung, H. S. (2000). Digital selection and analogue amplification coexist in a cortex- inspired silicon circuit. Nature, 405(6789), 947-951. https://doi.org/10.1038/35016072