Different combinations of gap repressors for common stripes in Anopheles and Drosophila embryos

Yury Goltsev, William Hsiong, Gregory Lanzaro, Mike Levine

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Drosophila segmentation is governed by a well-defined gene regulation network. The evolution of this network was investigated by examining the expression profiles of a complete set of segmentation genes in the early embryos of the mosquito, Anopheles gambiae. There are numerous differences in the expression profiles as compared with Drosophila. The germline determinant Oskar is expressed in both the anterior and posterior poles of Anopheles embryos but is strictly localized within the posterior plasm of Drosophila. The gap genes hunchback and giant display inverted patterns of expression in posterior regions of Anopheles embryos, while tailless exhibits an expanded pattern as compared with Drosophila. These observations suggest that the segmentation network has undergone considerable evolutionary change in the dipterans and that similar patterns of pair-rule gene expression can be obtained with different combinations of gap repressors. We discuss the evolution of separate stripe enhancers in the eve loci of different dipterans.

Original languageEnglish (US)
Pages (from-to)435-446
Number of pages12
JournalDevelopmental biology
Issue number2
StatePublished - Nov 15 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology
  • Developmental Biology


  • Diptera
  • Eve
  • Gap genes
  • Oskar
  • Segmentation
  • Stripe enhancers


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