TY - JOUR
T1 - Dif, a dorsal-related gene that mediates an immune response in Drosophila
AU - Ip, Y. Tony
AU - Reach, Michael
AU - Engstrom, Ylva
AU - Kadalayil, Latha
AU - Cai, Haini
AU - González-Crespo, Sergio
AU - Tatei, Kazuaki
AU - Levine, Michael
N1 - Funding Information:
The first two authors of this paper (Y. T. I. and M. R.) contributed equally to this work. We thank Christine Rushlow for sharing unpublished results, Steve Wasserman for providing mutant fly stocks, Ian Duncan for the YACs, and David Baltimore, Kees Murre, David Amosti, and Lily Mirels for critically reading the manuscript. This work was supported by a grant from the National Institutes of Health (NIH) (GM46638) to M L. and by the Swedish Natural Science Research Foundation, the Swedish Cancer Society, and the Carl Tryggers Stiftel-ese to Y. E.; Y. T. I. is a Hoffman-LaRoche fellow of the Life Sciences Research Foundation. M. R. is the recipient of an NIH postdoctoral fellowship. K. T. is a fellow of the Human Frontier Science Program. S. G.-C. is the recipient of a postdoctoral fellowship from the Spanish
PY - 1993/11/19
Y1 - 1993/11/19
N2 - There are striking parallels between the regulation of gene expression along the dorsoventral (DV) axis of Drosophila embryos and lymphoid-restricted expression in the mammalian immune system. Both depend on regulatory factors containing rel domains (dorsal and NF-κB) that are controlled at the level of nuclear transport. A novel Rel-containing gene in Drosophila, Dif (dorsal-related immunity factor), provides a potential link between these seemingly disparate processes. Although Dif maps close to dorsal, it does not appear to participate in DV patterning, but instead mediates an immune response in Drosophila larvae. Dif is normally localized in the cytoplasm of the larval fat body, but quickly accumulates in the nucleus upon bacterial infection or injury. Evidence is presented that once in the nucleus, Dif binds to κB-like sequence motifs present in promoter regions of immunity genes. These results suggest that mammalian and insect immunity share a common evolutionary origin.
AB - There are striking parallels between the regulation of gene expression along the dorsoventral (DV) axis of Drosophila embryos and lymphoid-restricted expression in the mammalian immune system. Both depend on regulatory factors containing rel domains (dorsal and NF-κB) that are controlled at the level of nuclear transport. A novel Rel-containing gene in Drosophila, Dif (dorsal-related immunity factor), provides a potential link between these seemingly disparate processes. Although Dif maps close to dorsal, it does not appear to participate in DV patterning, but instead mediates an immune response in Drosophila larvae. Dif is normally localized in the cytoplasm of the larval fat body, but quickly accumulates in the nucleus upon bacterial infection or injury. Evidence is presented that once in the nucleus, Dif binds to κB-like sequence motifs present in promoter regions of immunity genes. These results suggest that mammalian and insect immunity share a common evolutionary origin.
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U2 - 10.1016/0092-8674(93)90495-C
DO - 10.1016/0092-8674(93)90495-C
M3 - Article
C2 - 8242747
AN - SCOPUS:0027443688
VL - 75
SP - 753
EP - 763
JO - Cell
JF - Cell
SN - 0092-8674
IS - 4
ER -