Diet, nutrient supply, and tumor immune responses

Claire L. McIntyre, Ayantu Temesgen, Lydia Lynch

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Nutrients are essential for cell function. Immune cells operating in the complex tumor microenvironment (TME), which has a unique nutrient composition, face challenges of adapting their metabolism to support effector functions. We discuss the impact of nutrient availability on immune function in the tumor, competition between immune cells and tumor cells for nutrients, and how this is altered by diet. Understanding which diets can promote antitumor immune responses could open a new era of treatment, where dietary modifications can be used as an adjunct to boost the success of existing cancer therapies.

Original languageEnglish (US)
Pages (from-to)752-763
Number of pages12
JournalTrends in Cancer
Volume9
Issue number9
DOIs
StatePublished - Sep 2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • cancer
  • diet
  • immune cells
  • metabolism
  • obesity
  • T cells

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