Diet, nutrient supply, and tumor immune responses

Claire L. McIntyre; Ayantu Temesgen; Lydia Lynch

doi:10.1016/j.trecan.2023.06.003

Diet, nutrient supply, and tumor immune responses

Claire L. McIntyre, Ayantu Temesgen, Lydia Lynch

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Nutrients are essential for cell function. Immune cells operating in the complex tumor microenvironment (TME), which has a unique nutrient composition, face challenges of adapting their metabolism to support effector functions. We discuss the impact of nutrient availability on immune function in the tumor, competition between immune cells and tumor cells for nutrients, and how this is altered by diet. Understanding which diets can promote antitumor immune responses could open a new era of treatment, where dietary modifications can be used as an adjunct to boost the success of existing cancer therapies.

Original language	English (US)
Pages (from-to)	752-763
Number of pages	12
Journal	Trends in Cancer
Volume	9
Issue number	9
DOIs	https://doi.org/10.1016/j.trecan.2023.06.003
State	Published - Sep 2023
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Keywords

T cells
cancer
diet
immune cells
metabolism
obesity

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10.1016/j.trecan.2023.06.003

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title = "Diet, nutrient supply, and tumor immune responses",

abstract = "Nutrients are essential for cell function. Immune cells operating in the complex tumor microenvironment (TME), which has a unique nutrient composition, face challenges of adapting their metabolism to support effector functions. We discuss the impact of nutrient availability on immune function in the tumor, competition between immune cells and tumor cells for nutrients, and how this is altered by diet. Understanding which diets can promote antitumor immune responses could open a new era of treatment, where dietary modifications can be used as an adjunct to boost the success of existing cancer therapies.",

keywords = "T cells, cancer, diet, immune cells, metabolism, obesity",

author = "McIntyre, {Claire L.} and Ayantu Temesgen and Lydia Lynch",

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year = "2023",

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doi = "10.1016/j.trecan.2023.06.003",

language = "English (US)",

volume = "9",

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T1 - Diet, nutrient supply, and tumor immune responses

AU - McIntyre, Claire L.

AU - Temesgen, Ayantu

AU - Lynch, Lydia

PY - 2023/9

Y1 - 2023/9

N2 - Nutrients are essential for cell function. Immune cells operating in the complex tumor microenvironment (TME), which has a unique nutrient composition, face challenges of adapting their metabolism to support effector functions. We discuss the impact of nutrient availability on immune function in the tumor, competition between immune cells and tumor cells for nutrients, and how this is altered by diet. Understanding which diets can promote antitumor immune responses could open a new era of treatment, where dietary modifications can be used as an adjunct to boost the success of existing cancer therapies.

AB - Nutrients are essential for cell function. Immune cells operating in the complex tumor microenvironment (TME), which has a unique nutrient composition, face challenges of adapting their metabolism to support effector functions. We discuss the impact of nutrient availability on immune function in the tumor, competition between immune cells and tumor cells for nutrients, and how this is altered by diet. Understanding which diets can promote antitumor immune responses could open a new era of treatment, where dietary modifications can be used as an adjunct to boost the success of existing cancer therapies.

KW - T cells

KW - cancer

KW - diet

KW - immune cells

KW - metabolism

KW - obesity

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DO - 10.1016/j.trecan.2023.06.003

M3 - Review article

C2 - 37400315

AN - SCOPUS:85163544883

SN - 2405-8033

VL - 9

SP - 752

EP - 763

JO - Trends in Cancer

JF - Trends in Cancer

IS - 9

ER -

Diet, nutrient supply, and tumor immune responses

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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