Dielectric spectroscopy for bioanalysis: From 40 Hz to 26.5 GHz in a microfabricated wave guide

G. R. Facer, Daniel A. Notterman, L. L. Sohn

Research output: Contribution to journalArticle

133 Scopus citations

Abstract

We report developing coplanar waveguide devices which can perform dielectric spectroscopy on biological samples within a microfluidic channel or well. Since coupling to the fluid sample is capacitive, no surface functionalization or chemical sample preparation are required. Data on cell suspensions and solutions of proteins and nucleic acids spanning the frequency range from 40 Hz to 26.5 GHz are presented. Low-frequency data are well explained using a simple dispersion model. At microwave frequencies, the devices yield reproducible and distinguishable spectral responses for hemoglobin solution and live E. coli.

Original languageEnglish (US)
Pages (from-to)996-998
Number of pages3
JournalApplied Physics Letters
Volume78
Issue number7
DOIs
StatePublished - Feb 12 2001

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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