Dexamethasone up-regulates cadherin expression and cohesion of HT-1080 human fibrosarcoma cells

Ramsey A. Foty, Siobhan A. Corbett, Jean E. Schwarzbauer, Malcolm S. Steinberg

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The synthetic glucocorticoid dexamethasone markedly decreases the invasiveness of HT-1080 human fibrosarcoma cells. We show here that dexamethasone treatment of HT-1080 cell aggregates more than doubles their cohesivity from 3.9 to 9.7 dyne/cm. Western blot analysis shows a corresponding increase in cadherin expression. This was accompanied by an increase in the rate of calcium-dependent aggregation. Dexamethasone-treated aggregates spread to form a monolayer in Matrigel spreading assays, but the cells remained much more contiguous than their untreated counterparts. Invasion-suppression by dexamethasone may therefore be due, at least in part, to a previously unsuspected increase in cadherin-mediated cohesion.

Original languageEnglish (US)
Pages (from-to)3586-3589
Number of pages4
JournalCancer Research
Volume58
Issue number16
StatePublished - Aug 15 1998

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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