Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes

Diya Banerjee, Alvin Kwok, Shin Yi Lin, Frank J. Slack

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

In Caenorhabditis elegans, heterochronic genes constitute a developmental timer that specifies temporal cell fate selection. The heterochronic gene lin-42 is the C. elegans homolog of Drosophila and mammalian period, key regulators of circadian rhythms, which specify changes in behavior and physiology over a 24 hr day/night cycle. We show a role for two other circadian gene homologs, tim-1 and kin-20, in the developmental timer. Along with lin-42, tim-1 and kin-20, the C. elegans homologs of the Drosophila circadian clock genes timeless and doubletime, respectively, are required to maintain late-larval identity and prevent premature expression of adult cell fates. The molecular parallels between circadian and developmental timing pathways suggest the existence of a conserved molecular mechanism that may be used for different types of biological timing.

Original languageEnglish (US)
Pages (from-to)287-295
Number of pages9
JournalDevelopmental cell
Volume8
Issue number2
DOIs
StatePublished - Feb 1 2005

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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