Developmental Programs and Gene Expression Patterns Yield Insights Into the Evolution of Primate Cortical Circuitry

C. J. Charvet, F. M. Krienen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Primates delay neocortical neurogenesis and possess more neocortical neuron numbers compared with other studied taxa. We consider the consequences of evolutionary changes in developmental schedules on neuron numbers and expression of genes to identify evolutionary changes in cortical circuitry in primates. Delays in neocortical neurogenesis account for the expansion of neocortical neuron numbers and concomitant differences in laminar gene expression patterns between the neocortex of primates and rodents. Some of these differentially expressed genes are synaptic-related and reflect changes in connectivity patterns. We suggest that developmental timing accounts for greater intracortical connectivity in primates compared with other mammals.

Original languageEnglish (US)
Title of host publicationEvolution of Nervous Systems
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages91-97
Number of pages7
Volume3-4
ISBN (Electronic)9780128040423
ISBN (Print)9780128040966
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Keywords

  • Connections
  • Cortex
  • Development
  • Evolution
  • Gene expression
  • Layers
  • Neurogenesis
  • Primate
  • Pyramidal
  • Rodent

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