Abstract
Primates delay neocortical neurogenesis and possess more neocortical neuron numbers compared with other studied taxa. We consider the consequences of evolutionary changes in developmental schedules on neuron numbers and expression of genes to identify evolutionary changes in cortical circuitry in primates. Delays in neocortical neurogenesis account for the expansion of neocortical neuron numbers and concomitant differences in laminar gene expression patterns between the neocortex of primates and rodents. Some of these differentially expressed genes are synaptic-related and reflect changes in connectivity patterns. We suggest that developmental timing accounts for greater intracortical connectivity in primates compared with other mammals.
Original language | English (US) |
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Title of host publication | Evolution of Nervous Systems |
Subtitle of host publication | Second Edition |
Publisher | Elsevier Inc. |
Pages | 91-97 |
Number of pages | 7 |
Volume | 3-4 |
ISBN (Electronic) | 9780128040423 |
ISBN (Print) | 9780128040966 |
DOIs | |
State | Published - Jan 1 2016 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General Medicine
- General Neuroscience
Keywords
- Connections
- Cortex
- Development
- Evolution
- Gene expression
- Layers
- Neurogenesis
- Primate
- Pyramidal
- Rodent