Developmental enhancers and chromosome topology

Eileen E.M. Furlong, Michael Levine

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

Developmental enhancers mediate on/off patterns of gene expression in specific cell types at particular stages during metazoan embryogenesis. They typically integrate multiple signals and regulatory determinants to achieve precise spatiotemporal expression. Such enhancers can map quite far—one megabase or more—from the genes they regulate. How remote enhancers relay regulatory information to their target promoters is one of the central mysteries of genome organization and function. A variety of contrasting mechanisms have been proposed over the years, including enhancer tracking, linking, looping, and mobilization to transcription factories. We argue that extreme versions of these mechanisms cannot account for the transcriptional dynamics and precision seen in living cells, tissues, and embryos. We describe emerging evidence for dynamic three-dimensional hubs that combine different elements of the classical models.

Original languageEnglish (US)
Pages (from-to)1341-1345
Number of pages5
JournalScience
Volume361
Issue number6409
DOIs
StatePublished - Sep 28 2018

All Science Journal Classification (ASJC) codes

  • General

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