Development of potent inhibitors of pyocyanin production in pseudomonas aeruginosa

Laura C. Miller, Colleen T. O'Loughlin, Zinan Zhang, Albert Siryaporn, Justin E. Silpe, Bonnie L. Bassler, Martin F. Semmelhack

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P. aeruginosa. Interestingly, these new antagonists appear to suppress P. aeruginosa virulence factor production through a pathway that is independent of LasR and RhlR.

Original languageEnglish (US)
Pages (from-to)1298-1306
Number of pages9
JournalJournal of Medicinal Chemistry
Volume58
Issue number3
DOIs
StatePublished - Feb 12 2015

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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