Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks

Xiaojiang Feng; Joshua Rabinowitz; Herschel Rabitz

doi:10.1109/IPDPS.2008.4536416

Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks

Xiaojiang Feng, Joshua Rabinowitz, Herschel Rabitz

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper summarizes the development of laboratory and computational techniques for systematic and reliable understanding of metabolic networks. By combining a filter-based cell culture system and an optimized metabolite extraction protocol, a broad array of cellular metabolites can be reliably quantified following nutrient and other environment perturbations. A nonlinear closed-loop procedure was also developed for optimal bionetwork model identification. Computational illustrations and laboratory applications clearly demonstrate the capabilities of these techniques in understanding cellular metabolism, especially when they are integrated in an optimal fashion.

Original language	English (US)
Title of host publication	IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM
DOIs	https://doi.org/10.1109/IPDPS.2008.4536416
State	Published - 2008
Event	IPDPS 2008 - 22nd IEEE International Parallel and Distributed Processing Symposium - Miami, FL, United States Duration: Apr 14 2008 → Apr 18 2008

Publication series

Name	IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM

Other

Other	IPDPS 2008 - 22nd IEEE International Parallel and Distributed Processing Symposium
Country/Territory	United States
City	Miami, FL
Period	4/14/08 → 4/18/08

All Science Journal Classification (ASJC) codes

Hardware and Architecture
Software
Electrical and Electronic Engineering

Access to Document

10.1109/IPDPS.2008.4536416

Cite this

Feng, X., Rabinowitz, J., & Rabitz, H. (2008). Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks. In IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM Article 4536416 (IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM). https://doi.org/10.1109/IPDPS.2008.4536416

Feng, Xiaojiang ; Rabinowitz, Joshua ; Rabitz, Herschel. / Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks. IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM. 2008. (IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM).

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title = "Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks",

abstract = "This paper summarizes the development of laboratory and computational techniques for systematic and reliable understanding of metabolic networks. By combining a filter-based cell culture system and an optimized metabolite extraction protocol, a broad array of cellular metabolites can be reliably quantified following nutrient and other environment perturbations. A nonlinear closed-loop procedure was also developed for optimal bionetwork model identification. Computational illustrations and laboratory applications clearly demonstrate the capabilities of these techniques in understanding cellular metabolism, especially when they are integrated in an optimal fashion.",

author = "Xiaojiang Feng and Joshua Rabinowitz and Herschel Rabitz",

year = "2008",

doi = "10.1109/IPDPS.2008.4536416",

language = "English (US)",

isbn = "9781424416943",

series = "IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM",

booktitle = "IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM",

note = "IPDPS 2008 - 22nd IEEE International Parallel and Distributed Processing Symposium ; Conference date: 14-04-2008 Through 18-04-2008",

}

Feng, X, Rabinowitz, J & Rabitz, H 2008, Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks. in IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM., 4536416, IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM, IPDPS 2008 - 22nd IEEE International Parallel and Distributed Processing Symposium, Miami, FL, United States, 4/14/08. https://doi.org/10.1109/IPDPS.2008.4536416

Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks. / Feng, Xiaojiang; Rabinowitz, Joshua ; Rabitz, Herschel.
IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM. 2008. 4536416 (IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - This paper summarizes the development of laboratory and computational techniques for systematic and reliable understanding of metabolic networks. By combining a filter-based cell culture system and an optimized metabolite extraction protocol, a broad array of cellular metabolites can be reliably quantified following nutrient and other environment perturbations. A nonlinear closed-loop procedure was also developed for optimal bionetwork model identification. Computational illustrations and laboratory applications clearly demonstrate the capabilities of these techniques in understanding cellular metabolism, especially when they are integrated in an optimal fashion.

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BT - IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM

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Feng X, Rabinowitz J , Rabitz H. Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks. In IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM. 2008. 4536416. (IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM). doi: 10.1109/IPDPS.2008.4536416

Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks

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