Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper summarizes the development of laboratory and computational techniques for systematic and reliable understanding of metabolic networks. By combining a filter-based cell culture system and an optimized metabolite extraction protocol, a broad array of cellular metabolites can be reliably quantified following nutrient and other environment perturbations. A nonlinear closed-loop procedure was also developed for optimal bionetwork model identification. Computational illustrations and laboratory applications clearly demonstrate the capabilities of these techniques in understanding cellular metabolism, especially when they are integrated in an optimal fashion.

Original languageEnglish (US)
Title of host publicationIPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM
DOIs
StatePublished - Sep 10 2008
EventIPDPS 2008 - 22nd IEEE International Parallel and Distributed Processing Symposium - Miami, FL, United States
Duration: Apr 14 2008Apr 18 2008

Publication series

NameIPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM

Other

OtherIPDPS 2008 - 22nd IEEE International Parallel and Distributed Processing Symposium
CountryUnited States
CityMiami, FL
Period4/14/084/18/08

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Software
  • Electrical and Electronic Engineering

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  • Cite this

    Feng, X., Rabinowitz, J., & Rabitz, H. (2008). Development of laboratory and computational techniques for optimal and quantitative understanding of cellular metabolic networks. In IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM [4536416] (IPDPS Miami 2008 - Proceedings of the 22nd IEEE International Parallel and Distributed Processing Symposium, Program and CD-ROM). https://doi.org/10.1109/IPDPS.2008.4536416