Development of CD1d-restricted NKT cells in the mouse thymus

Tao Dao, Donglin Guo, Alexander Ploss, Amy Stolzer, Carolyn Saylor, Tamar E. Boursalian, Jin Seon Im, Derek B. Sant'Angelo

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Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4+CD8+ stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations.

Original languageEnglish (US)
Pages (from-to)3542-3552
Number of pages11
JournalEuropean Journal of Immunology
Issue number12
StatePublished - Dec 1 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


  • CD1d
  • T cell receptor
  • Thymus
  • iNKT cells

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    Dao, T., Guo, D., Ploss, A., Stolzer, A., Saylor, C., Boursalian, T. E., Im, J. S., & Sant'Angelo, D. B. (2004). Development of CD1d-restricted NKT cells in the mouse thymus. European Journal of Immunology, 34(12), 3542-3552.