Development of an approach to the synthesis of the plakortones

M. F. Semmelhack, Ponnusamy Shanmugam

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


A general synthesis of the plakortones has been developed by the synthesis of two key sections, with a focus on Pd(II)-promoted preparation of a cis-fused tetrahydrofuranolactone. The key intermediates were obtained in homochiral form starting from asymmetric epoxidation of an allylic alcohol. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)3567-3571
Number of pages5
JournalTetrahedron Letters
Issue number19
StatePublished - May 6 2000

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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