A general synthesis of the plakortones has been developed by the synthesis of two key sections, with a focus on Pd(II)-promoted preparation of a cis-fused tetrahydrofuranolactone. The key intermediates were obtained in homochiral form starting from asymmetric epoxidation of an allylic alcohol. (C) 2000 Elsevier Science Ltd.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry