Development and application of expressed protein ligation

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21 Scopus citations


Expressed protein ligation (EPL) is a protein semi-synthesis approach that allows synthetic and recombinant polypeptides to be chemoselectively and regioselectively joined together via a peptide bond. The approach makes the primary structure of proteins accessible to the tools of synthetic organic chemistry and thus provides expanded opportunities in the area of protein engineering. The development and application of this process will be discussed.

Original languageEnglish (US)
Pages (from-to)733-740
Number of pages8
Issue number6
StatePublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


  • Chemical ligation
  • Inteins
  • Semi-synthesis


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