TY - JOUR
T1 - Deterministic Lateral Displacement
T2 - Challenges and Perspectives
AU - Hochstetter, Axel
AU - Vernekar, Rohan
AU - Austin, Robert H.
AU - Becker, Holger
AU - Beech, Jason P.
AU - Fedosov, Dmitry A.
AU - Gompper, Gerhard
AU - Kim, Sung Cheol
AU - Smith, Joshua T.
AU - Stolovitzky, Gustavo
AU - Tegenfeldt, Jonas O.
AU - Wunsch, Benjamin H.
AU - Zeming, Kerwin K.
AU - Krüger, Timm
AU - Inglis, David W.
N1 - Funding Information:
A.H. gratefully acknowledges the funding of the Swiss National Science Foundation (P2BSP2_172033) and Animalfree Research (Switzerland). T.K. received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (803553). J.B. and J.T. carried out this work within NanoLund at Lund University with funding from the European Union, under the Seventh Framework Programme FP7/2007-2013/within the project LAPASO (607350), under Horizon 2020/FETOPEN within the project evFOUNDRY (801367), and under Horizon2020/HEALTH within the project BeyondSeq (634890) as well as from the Swedish Research council (2016-05739). K.K.Z. is supported by the National Research Foundation, Prime Minister’s Office, Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) programme, through Singapore MIT Alliance for Research and Technology (SMART): Critical Analytics for Manufacturing Personalised-Medicine (CAMP) Inter-Disciplinary Research Group.
Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/9/22
Y1 - 2020/9/22
N2 - The advent of microfluidics in the 1990s promised a revolution in multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous-flow microfluidic particle separation method discovered in 2004 that has been applied successfully and widely to the separation of blood cells, yeast, spores, bacteria, viruses, DNA, droplets, and more. Deterministic lateral displacement is conceptually simple and can deliver consistent performance over a wide range of flow rates and particle concentrations. Despite wide use and in-depth study, DLD has not yet been fully elucidated or optimized, with different approaches to the same problem yielding varying results. We endeavor here to provide up-to-date expert opinion on the state-of-art and current fundamental, practical, and commercial challenges with DLD as well as describe experimental and modeling opportunities. Because these challenges and opportunities arise from constraints on hydrodynamics, fabrication, and operation at the micro- and nanoscale, we expect this Perspective to serve as a guide for the broader micro- and nanofluidic community to identify and to address open questions in the field.
AB - The advent of microfluidics in the 1990s promised a revolution in multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous-flow microfluidic particle separation method discovered in 2004 that has been applied successfully and widely to the separation of blood cells, yeast, spores, bacteria, viruses, DNA, droplets, and more. Deterministic lateral displacement is conceptually simple and can deliver consistent performance over a wide range of flow rates and particle concentrations. Despite wide use and in-depth study, DLD has not yet been fully elucidated or optimized, with different approaches to the same problem yielding varying results. We endeavor here to provide up-to-date expert opinion on the state-of-art and current fundamental, practical, and commercial challenges with DLD as well as describe experimental and modeling opportunities. Because these challenges and opportunities arise from constraints on hydrodynamics, fabrication, and operation at the micro- and nanoscale, we expect this Perspective to serve as a guide for the broader micro- and nanofluidic community to identify and to address open questions in the field.
UR - http://www.scopus.com/inward/record.url?scp=85091043486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85091043486&partnerID=8YFLogxK
U2 - 10.1021/acsnano.0c05186
DO - 10.1021/acsnano.0c05186
M3 - Review article
C2 - 32844655
AN - SCOPUS:85091043486
SN - 1936-0851
VL - 14
SP - 10784
EP - 10795
JO - ACS Nano
JF - ACS Nano
IS - 9
ER -